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Real members of MGteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I was taking mestinon Five times a day doctor wants me to reduce to three times a day. What times would be best to take it?

A MGteam Member asked a question 💭
Coral Springs, FL
July 7
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A MGteam Member

Gerald - I take 60mg 5x a day. 7am, 10am, 1pm, 4pm and last one at 7pm. Cellcept 250mg 2x a day 7am then 5:30pm.

I’m going to go to 4x a day and see how it works. 7am 11am 3pm and 7pm.

If I take meds too late it keeps me up at night.

July 7
A MGteam Member

Youre right Greg - I’m also doing pretty good but I have my moments like we all do - just when you think you’re doing ok you get a reminder don’t forget about MG.

July 7
A MGteam Member

Hi carol that’s good news if doctor wants to reduce meds. I was taking 60mg mestinon 3x a day. 7am,noon,5 pm along with 10 mg prednisone 1st thing in morning. It took about 3 weeks for mestinon to help with double vision. My doc reduced mestinon to 2x a day I tried mid morning and mid afternoon and my eyes said hell no. I had to go back to 3x a day. I’m doing pretty good now. I hate to respond to these due to the fact there are people a lot worse off than me. I pray everyone finds comfort in this life.

July 7
MGteam

Switching to three times a day is a big change, and timing it well can really help you get the most out of each dose. Since Mestinon (pyridostigmine) works best about 1 to 1.5 hours after taking it, it helps to plan your day around those peak windows.

Here are some general timing tips to consider:

- Morning dose — Take it Show Full Answer

Switching to three times a day is a big change, and timing it well can really help you get the most out of each dose. Since Mestinon (pyridostigmine) works best about 1 to 1.5 hours after taking it, it helps to plan your day around those peak windows.

Here are some general timing tips to consider:

- Morning dose — Take it early so you're at peak strength when you need it most. Many people with MG feel strongest in the morning.
- Midday dose — Space it out evenly to help carry you through the afternoon, when fatigue can start to creep in.
- Evening dose — Time it before your last meal or any evening activities you need energy for.

A few extra things to keep in mind:

- Eat meals during your peak window — about an hour after each dose, when swallowing and chewing are easier.
- Schedule physical activity around 1.5 to 2 hours after a dose for the best muscle support.
- Muscle weakness tends to worsen later in the day, so front-loading your energy with a well-timed morning dose can be really helpful.

Since everyone's routine is different, it's worth discussing the exact timing with your neurologist or pharmacist to fit your specific schedule and symptoms.

July 7
A MGteam Member

My dr started me on 30mg 3 times a day that’s the only dosage I’ve ever had so far 6 weeks in

July 7

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