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Real members of MGteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I have hashimoto’s and psoriatic arthritis. Blood test for mg detected antibodies but below diagnostic threshold. Neurologist said EMG was negative for MG but did show some muscle weakness particularly in shoulders and upper arms. I had a period of difficulty getting a deep breath that lasted 3 1/2 years then resolved for 7 years. Returned along with difficulty swallowing, chewing, fatigue and weakness in arms. Asked for a mestinon trial but Dr says you are negative for MG. I am curious if… read more

August 3, 2025
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It's important to note that medications and supplements can affect MG blood test results. A normal or below-threshold antibody test result doesn't definitively rule out MG. Between 6-10% of people with MG have neither detectable AChR nor MuSK antibodies, which is known as seronegative MG.

The symptoms described (breathing Show Full Answer

It's important to note that medications and supplements can affect MG blood test results. A normal or below-threshold antibody test result doesn't definitively rule out MG. Between 6-10% of people with MG have neither detectable AChR nor MuSK antibodies, which is known as seronegative MG.

The symptoms described (breathing difficulties, swallowing problems, fatigue, and arm weakness) are consistent with MG symptoms. One MGteam member was diagnosed based on symptoms, nerve conduction studies, and response to Mestinon despite having negative bloodwork. Getting appropriate treatment within six months of initial symptoms typically leads to better outcomes. If standard antibody tests are negative, neurologists may recommend testing for other autoantibodies like LRP4 or anti-striated muscle antibodies. Some cases of seronegative MG may be caused by antibodies that scientists haven't yet identified.

August 3, 2025

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