Hi Rosie. I have seronegative generalized MG too.
Tried pyridostigmine which helped however had awful diarrhea side effects. ( If sensitive to lactose , consider requesting the LACTOSE free filler pyridostigmine product)
As you probably know, treatment options for seronegative MG patients are limited.
Prescribed IVIG and despite a classic reaction felt so much better 4 days later ( WoW!) The improvement did not last more than 1 month. IVIG treatment is like a band aid , just for a quick pick you up .
Next , my NEURO doc suggested Two different immunosuppressive treatments : oral CELLCEPT which sadly takes around 6 months to work and also RITUXIMAB IV infusion ( every 6 month ) which can work quicker around 2- 4 months .
Opted to only try the RITUXIMAB and not take two immunosuppressive meds at the same time. Currently , Healing from cataract surgery and have taken the vaccinations needed before starting this IV infusion treatment in around the next month or so.
Another option for folks like us who are seronegative , is to have your NEURO doc list your abnormal tests, like if you are SINGLE FIBER EMG abnormal positive & your symptoms to request some other MG treatments not usually available to seronegative MG patients , like VyVgart , which may be approved by your insurance company . VyVgart is a promising treatment for MG .
For other options, Some studies have been completed for treatment for seronegative MG patients and we have to wait for FDA approval of these medications.
Must have a knowledgeable NEUROMUSCULAR doc who can guide you of MG treatments available to seronegative MG patients.
Finding the right MG treatment cocktail with the least side effects is part of our treatment journey.
Must have FAITH !

I'm seronegative Rosie and my doctor put me on Pyridostigmine 30 mg, but so far, I haven't noticed any difference in my oMG symptoms. Sorry.....wish I could give you a more positive answer. 🤪