MGteam

It sounds like leg fatigue is really getting in the way, even with Mestinon and prednisone on board. That's genuinely frustrating, and you're not alone in this experience.

It's worth knowing that fatigue in MG doesn't always track directly with muscle weakness. Research has found that fatigue can persist even when MG is Show Full Answer

It sounds like leg fatigue is really getting in the way, even with Mestinon and prednisone on board. That's genuinely frustrating, and you're not alone in this experience.

It's worth knowing that fatigue in MG doesn't always track directly with muscle weakness. Research has found that fatigue can persist even when MG is well-controlled or in remission — meaning it can sometimes have a life of its own. One MGteam member described it well: there's the fatigue of specific muscles (like legs giving out), and then there's a whole-body crushing weariness that's a different beast entirely. Both are real and valid.

A few things worth discussing with your neurology team:

- Medication adjustment — dosage or timing of Mestinon can sometimes make a difference
- Adding physical or occupational therapy — gentle, conscious movement and stretching can help
- Screening for depression — it's more common with MG and can worsen fatigue significantly
- Ruling out other contributing factors — blood tests can help identify what else might be going on If your current treatment plan isn't cutting it, that's important information for your neurologist. There are other treatment options beyond Mestinon and prednisone worth exploring together with your care team.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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