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Real members of MGteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MGteam Member asked a question 💭
Coral Springs, FL
July 2
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A MGteam Member

Yes sorry harmless

July 8
A MGteam Member

Tou are experiencing Flashulasions, not sure on the spelling ,I experience them to even after 15 years on Mestinan. They are a aide effect of the stigmine and my neurologist stated they are not harmless. I experience them in my calfs and biceps. Looks like you are have multiple strings pulling different parts of muscle but under the skin. I also every now and then get jerky , like I was suddenly electrocuted.

July 5
A MGteam Member

This is good advice ,I make sure I don't take my last dose until5:00 and I go to bed at 11 sleep much better before I was taking my last dose about 8 and I was wired up when I went to bed , plus imy does was to high , now I have very little leg cramps, and haven't noticed any twitching at all❤

July 3
A MGteam Member

Hey CarolErdman

For me the fluttering and twitching was 2 things.
1. My dose was too high
2. I was taking it at bed time
My doc said to take it 1 hour before or after a meal and never before bed. Because its a muscle builder I/we need to move about after you take it. Depending on when your day starts and ends.

July 2
MGteam

That twitching or fluttering feeling after taking Mestinon (pyridostigmine) is actually related to how the medication works. Mestinon increases the amount of acetylcholine available at the nerve-muscle junction, which helps muscles contract more effectively. Sometimes, this boost can cause small, involuntary muscle twitches Show Full Answer

That twitching or fluttering feeling after taking Mestinon (pyridostigmine) is actually related to how the medication works. Mestinon increases the amount of acetylcholine available at the nerve-muscle junction, which helps muscles contract more effectively. Sometimes, this boost can cause small, involuntary muscle twitches as your muscles respond to the increased signaling. However, it's worth paying attention to how intense or frequent these twitches are. If the dose is too high, it can lead to something called a cholinergic crisis — meaning there's too much acetylcholine in your system. Warning signs to watch for include:

- Trouble breathing
- Increased saliva or sweating
- Nausea or vomiting
- Blurry vision
- Low heart rate

If any of these accompany the twitching, contact your doctor or seek medical attention right away.

Even if the twitching feels mild, it's still a good idea to mention it to your MG specialist. They may want to review your dosage or timing to make sure everything is dialed in just right for you.

July 2

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A MGteam Member asked a question 💭
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A MGteam Member asked a question 💭
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