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Hi i take pyrostogmin 90 mg 4 times a day and get such bad cramps is there any iv drug approved if you have seronegative mg ?

A MGteam Member asked a question 💭
NC
December 2, 2025
 · 
Reactions
A MGteam Member

Thanks Johanna. Have a great holiday seaso

December 3, 2025
A MGteam Member

When I got cramps I've found that pickle juice clears it up in seconds. Any extended pain I just let my neuro know as well. Thankfully he never changed my rx

December 2, 2025
A MGteam Member

Hi Cynthia3, I can sure identify with you about having muscle cramps while on Pyridostigmine. I had horrific leg cramps all night long that just wouldn't quit. My doctor took me off of Pyridostigmine and started me on Vyvgart infusions. I'm doing well on those so far. I'm starting my second round of four infusions the middle of December. Wishing you the very best and hope you find good results with Vyvgart as well. Merry Christmas too! 😊

December 2, 2025
MGteam

Are there any IV drug options approved for seronegative MG, and what about those cramps from pyridostigmine?

First, about those cramps - you're definitely not alone. Studies show that between 30 to 40 percent of people taking pyridostigmine report muscle cramps. The discomfort often follows the same pattern as MG symptoms Show Full Answer

Are there any IV drug options approved for seronegative MG, and what about those cramps from pyridostigmine?

First, about those cramps - you're definitely not alone. Studies show that between 30 to 40 percent of people taking pyridostigmine report muscle cramps. The discomfort often follows the same pattern as MG symptoms, starting in the eyes and face, then potentially spreading to the neck, arms, and legs.

Some strategies that have helped MGteam members include:
- Conscious exercise and stretching (without overdoing it)
- Muscle massage
- Over-the-counter pain relievers like acetaminophen or ibuprofen

It's worth discussing your cramping with your doctor, as they may be able to adjust your medication timing or dosage. Regarding IV treatment for seronegative MG - there's promising news. Efgartigimod (Vyvgart) recently showed positive results in a phase 3 trial specifically for people with seronegative MG, including those who are MuSK-positive, LRP4-positive, or triple seronegative.

The study found statistically significant improvements in daily function for activities like speaking, chewing, and swallowing. The drug was well-tolerated with side effects similar to previous studies.

The manufacturer plans to ask the FDA to expand approval for seronegative MG, which could provide more treatment options. Talk with your neurologist about whether this might be appropriate for your situation and what your current treatment options include.

December 2, 2025
A MGteam Member

Im having the same problems. Im trying to break my pills up and put them under my tongue. Seems to be helping. Ask your Dr what they think. I've heard yes you can and no you cant.

December 8, 2025

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