Connect with others who understand.

  •   Learn from expert-reviewed resources
  •   Real advice from people who’ve been there
  •   People who understand what you’re going through
Sign Up Log In
Powered By
Real members of MGteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MGteam Member asked a question 💭
Tunisie

Can radiotherapy worsen symptoms in a patient with Myasthenia Gravis (MG)?
The patient has Myasthenia Gravis and is currently receiving radiotherapy. The patient takes Mestinon 60 mg, six tablets every two and a half hours.
Could radiotherapy worsen the patient's symptoms or increase the risk of a myasthenic crisis? Are any special precautions or adjustments to the treatment necessary?

October 9
 · 
Be the first to react
MGteam

Radiotherapy and its potential impact on MG symptoms is an important concern. While radiotherapy itself isn't directly listed as a known MG trigger, several related factors could increase risk during treatment.

Key concerns to be aware of include:

- Infection risk — Radiotherapy can weaken the immune system, and infections Show Full Answer

Radiotherapy and its potential impact on MG symptoms is an important concern. While radiotherapy itself isn't directly listed as a known MG trigger, several related factors could increase risk during treatment.

Key concerns to be aware of include:

- Infection risk — Radiotherapy can weaken the immune system, and infections are one of the most common triggers of a myasthenic crisis
- Physical stress — The body stress of ongoing treatment can worsen MG symptoms
- Fatigue and heat — Both are known MG triggers and are common side effects of radiotherapy
- Medication interactions — Any additional medications given alongside radiotherapy should be checked for MG compatibility Given the current Mestinon dosage (60mg, six tablets every 2.5 hours), which is already at the higher end of typical dosing, it's especially important that all treating doctors — including the radiotherapy team — are fully aware of the MG diagnosis and current medications.

Some important precautions include:

- Inform every specialist involved in radiotherapy care about the MG diagnosis
- Watch for infection signs and report them immediately, as infections can trigger a myasthenic crisis
- Monitor breathing carefully, as any respiratory changes need urgent medical attention
- Discuss any new medications prescribed during radiotherapy with a neurologist first

A myasthenic crisis is a serious risk if symptoms worsen, so having a clear action plan with the neurology team before and during radiotherapy is strongly recommended.

October 9