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I’ve been diagnosed with type2 diabetes, can this interfere with MG or the medication Metformin?

A MGteam Member asked a question 💭
Eastbourne, UK

I’m sure there are others with MG and Diabetes? I find after taking them, my muscles are so weak?

1 day ago
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A MGteam Member

I have all kinds of problems with it. Prednisone is a major culprit. I’m on Majuro 10 once a week and 10 to 20 units of sola star insulin daily. Prednisone will depending on the dose will jump me 200 points.

17 hours ago
A MGteam Member

Hi Carol,
Thank you for getting back to me so quickly & thank you for your support. It was only a month ago, that my GP said your Blood results came back with a 5.2 diabetes level and I would need to go on Meds. This is a very low result as 4.8 is normal. I believe this has been raised by Prednisolone and when I ask her she said well could be. She made an appt for the diabetic nurse, who put me straight on Metformin 500grms and increasing it asap 2,000 grand per day. I believe it’s too much & my bloods show I’m very low. I really think they just chuck you on the meds to day another customer box ticked.

I will see, when I have my next full blood test to see.

Sue 🙂

21 hours ago
A MGteam Member

Hi Susan - I’ve been diagnosed with diabetes I’m assuming due to meds too as I’ve never been a diabetic. I’m on glipizide xl 250mg. I did notice one day at work I almost felt I was going to collapse that was scary. I now make sure I have a candy or an orange to take and then sit down.

I’m hoping in 3 months I’ll be off pill and my a1c will be back to normal.

Crazy journey - you take pills to help one disease and then you get another ugh!!!!!

1 day ago
MGteam

Having both MG and type 2 diabetes is more common than you might think — and you're definitely not alone in navigating this. Research has found that people with MG who take corticosteroids (like prednisone) have a significantly higher risk of developing type 2 diabetes, so the two conditions often go hand in hand.

The good Show Full Answer

Having both MG and type 2 diabetes is more common than you might think — and you're definitely not alone in navigating this. Research has found that people with MG who take corticosteroids (like prednisone) have a significantly higher risk of developing type 2 diabetes, so the two conditions often go hand in hand.

The good news is that if steroids were contributing to high blood sugar, reducing or stopping them (under doctor guidance) can often bring blood sugar back to normal levels. Regarding Metformin and muscle weakness — this is worth raising with your neurologist and prescribing doctor. While Metformin itself isn't widely flagged as a known MG trigger, increased muscle weakness after starting a new medication should always be taken seriously with MG.

Some things worth discussing with your healthcare team:

- Whether your current MG medications interact with Metformin
- Whether the timing of doses could be adjusted
- Whether the weakness is related to blood sugar fluctuations rather than the medication itself

Low or unstable blood sugar can also cause fatigue and weakness, which can feel very similar to MG symptoms — making it tricky to untangle what's causing what. Many MGteam members manage both conditions and share tips on balancing treatments. The most important step right now is letting your neurology team and diabetes doctor know about the muscle weakness you're experiencing after taking Metformin — don't wait on that one.

1 day ago
A MGteam Member

Prednisone and cellcept too jumped my blood glucose levels through the roof

3 hours ago

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Hello fine folks in the MG group!

A MGteam Member asked a question 💭
Wilmington, NC
December 8, 2025