It sounds like the question got cut off — but it seems like you're asking what other tests might help with a seronegative generalized MG diagnosis after 20 months. That's a long time to be waiting for answers, and it's completely understandable to want more clarity.
Given your situation, there are several tests worth Show Full Answer
It sounds like the question got cut off — but it seems like you're asking what other tests might help with a seronegative generalized MG diagnosis after 20 months. That's a long time to be waiting for answers, and it's completely understandable to want more clarity.
Given your situation, there are several tests worth discussing with your neurologist:
- Cell-based assay — a newer, more precise blood test using living cells to detect antibodies. Studies show nearly 1 in 5 people originally diagnosed as seronegative actually had AChR antibodies when this test was used
- LRP4 antibody testing — about 1% of seronegative MG patients test positive for this antibody
- CT scan or MRI of the chest — to check the thymus gland for abnormalities, which is especially important with generalized MG symptoms
- Single-fiber EMG (SFEMG) — a more sensitive version of the EMG you've already had, and considered the gold standard for detecting neuromuscular junction problems
- Repetitive nerve stimulation (RNS) — another electrodiagnostic test that checks how muscles respond under repeated nerve signals Bringing a list of these tests to your next neurology appointment could be a great way to advocate for a more complete workup. Early and accurate diagnosis really does make a difference in outcomes.
August 21
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