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Real members of MGteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MGteam Member asked a question 💭
Traverse City, MI
June 3
 · 
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A MGteam Member

You have to be careful with antibiotics, there are certain ones you must avoid completely!! And regular drs are not always aware of this! In the ER one time I almost got sent into a crisis, thank goodness another dr came in and made them switch antibiotics they was about to give me!! I usually get started out on the “weakest” type like amoxicillin. If you google it it will tell what groups or specific ones to avoid, can’t say I remember them either at the moment.

June 16
MGteam

Yes, certain antibiotics can worsen MG symptoms and should be avoided when possible. These antibiotics can interfere with the way nerves communicate with muscles, leading to increased muscle weakness.

The antibiotics generally considered risky for people with MG include:

- Fluoroquinolones (e.g., ciprofloxacin Show Full Answer

Yes, certain antibiotics can worsen MG symptoms and should be avoided when possible. These antibiotics can interfere with the way nerves communicate with muscles, leading to increased muscle weakness.

The antibiotics generally considered risky for people with MG include:

- Fluoroquinolones (e.g., ciprofloxacin, levofloxacin) — can cause breathing problems, swallowing difficulties, drooping eyelids, and double vision
- Macrolides (e.g., azithromycin, clarithromycin) — can reduce the effectiveness of acetylcholine, which is already impaired in MG
- Aminoglycosides (e.g., gentamicin, tobramycin) — risk is higher for those who also have kidney issues
- Some tetracyclines (e.g., doxycycline, minocycline) There are safer antibiotic options that are generally better tolerated with MG, including:

- Penicillins (e.g., amoxicillin, ampicillin)
- Cephalosporins (e.g., cephalexin, ceftriaxone)
- Vancomycin (used for severe or resistant infections)
- Trimethoprim-sulfamethoxazole (Bactrim/Septra)
- Nitrofurantoin (especially for urinary tract infections)

It's important to always check with your MG specialist or neurologist before taking any antibiotic, as sometimes treating an infection is critical — and in some cases, the infection itself can trigger an MG flare.

June 3

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