Did you initially test negative for antibodies and later test positive?
Yes, this can happen. Some MGteam members have shared similar experiences. One member mentioned that their blood work didn't confirm MG initially, and it took an EMG to get their diagnosis confirmed. Another member shared that it took three years to Show Full Answer
Did you initially test negative for antibodies and later test positive?
Yes, this can happen. Some MGteam members have shared similar experiences. One member mentioned that their blood work didn't confirm MG initially, and it took an EMG to get their diagnosis confirmed. Another member shared that it took three years to get diagnosed.
There are a few reasons why you might test negative initially but still have MG:
* Newer, more sensitive testing methods (like cell-based assays) can detect antibodies that older tests miss
* Almost one-fifth of people originally thought to be seronegative actually had AChR antibodies when tested with more precise methods
* Some medications, illnesses, or other factors may affect blood test results
About 10% of people with MG have seronegative (or double-negative) MG, meaning they don't have the common AChR or MuSK antibodies. Some of these individuals may have other antibodies like LRP4 or agrin antibodies that aren't routinely tested for yet. It's good that you're seeing a neurologist for further testing. They may recommend additional tests beyond blood work, such as:
* Repetitive nerve stimulation
* Single fiber electromyography (EMG)
* Testing for other antibodies like LRP4 or anti-striated muscle antibodies
The diagnostic process can take time, but getting a thorough evaluation will help ensure you receive the right diagnosis and treatment plan.
February 9
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