What does it mean if both AChR and Anti-MuSK antibody tests are negative?
This means you may have what's called "double-seronegative myasthenia gravis," which occurs in about 6-10% of people with MG. Having negative test results for both antibodies doesn't rule out having MG - it's just a different type. People with Show Full Answer
What does it mean if both AChR and Anti-MuSK antibody tests are negative?
This means you may have what's called "double-seronegative myasthenia gravis," which occurs in about 6-10% of people with MG. Having negative test results for both antibodies doesn't rule out having MG - it's just a different type. People with seronegative myasthenia gravis are more likely to have ocular symptoms (affecting the eyes) compared to those with positive antibody tests. Your neurologist may recommend additional testing for other antibodies, such as LRP4, to help confirm the diagnosis.
Remember that diagnosis isn't based solely on blood tests - your doctor will consider your symptoms and may use other diagnostic tools like electromyography to confirm MG.
September 14, 2025