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A MGteam Member asked a question 💭
Monroe, NY
July 20, 2025
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MGteam

Yes! While about 85% of people with MG have positive AChR antibodies, approximately 15% test negative. This is completely normal and doesn't make your MG diagnosis any less valid.

If you test negative for AChR antibodies, your doctor may test for other antibodies like MuSK, which is found in 30-40% of people who are AChR Show Full Answer

Yes! While about 85% of people with MG have positive AChR antibodies, approximately 15% test negative. This is completely normal and doesn't make your MG diagnosis any less valid.

If you test negative for AChR antibodies, your doctor may test for other antibodies like MuSK, which is found in 30-40% of people who are AChR negative. Some people (about 6-10%) test negative for both AChR and MuSK antibodies - this is called double-seronegative MG. People with seronegative MG often experience:

- Ocular symptoms (affecting the eyes)
- Bulbar weakness (affecting speaking/swallowing)
- More common in females
- Tends to develop at younger ages

Remember, treatment options are similar regardless of antibody status, and your neurologist will help develop the most effective plan for your specific needs.

July 20, 2025
A MGteam Member

I have no antibodies. No matter how many blood tests or vaxx I take.

July 20, 2025
A MGteam Member

I am also seronegative. I was extremely lucky to get in with a neurologist who has experience with MG especially since I had no clue what was wrong with me & neither did my GP or rheumatologist.

July 23, 2025
A MGteam Member

Hi Lise! I am totally seronegative; I've tested negative for ALL the antibodies. We're part of a smaller 'community' than MG warriors in general, as the AI-generated answer indicates. Sadly, I think it's not uncommon for doctors, and even neurologists in some cases, who haven't worked much with myasthenia patients to rule out MG as a diagnosis when the tests come back negative. But highly informed physicians with experience treating MG patients will look past the antibody tests and make a diagnosis based on symptoms and (in my case) response to treatment. If you're antibody negative and still have a diagnosis of MG, you must have found one of the good, open-minded ones!

Hope you're doing well and that the week ahead is a good one! ❤️wm

July 20, 2025

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