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Real members of MGteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MGteam Member asked a question 💭
Westland, MI
April 3, 2025
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There are three main classes of antibiotics that people with myasthenia gravis should be particularly careful about:

Macrolides (like azithromycin/Zithromax) can worsen muscle weakness symptoms because they interfere with acetylcholine release at the neuromuscular junction.

Fluoroquinolones (like ciprofloxacin/Cipro) can Show Full Answer

There are three main classes of antibiotics that people with myasthenia gravis should be particularly careful about:

Macrolides (like azithromycin/Zithromax) can worsen muscle weakness symptoms because they interfere with acetylcholine release at the neuromuscular junction.

Fluoroquinolones (like ciprofloxacin/Cipro) can cause severe symptom flares by blocking acetylcholine's ability to help muscles contract. This can lead to breathing problems, swallowing difficulties, drooping eyelids, and double vision. Aminoglycosides (like neomycin) may also worsen MG symptoms, with higher risks for those who have kidney problems.

It's essential to always consult with your neurologist or MG specialist before starting any antibiotic treatment. They can help evaluate the risks versus benefits and choose the safest option for your specific situation. Sometimes treating an infection may be more important than the risk of symptom exacerbation.

April 3, 2025

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