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I am really new to this and dx in April as ocular MG post ice pack test for ptosis (it just started a week or so before appt). All my labs were seronegative. I got referred for CT to check thymus (nothing identified) and for a SFEMG. I had my nerve conduction and SFEMG yesterday- results showed 5 jitters and was “abnormal “ but report said that since I had dysport (Botox) 6 months before it might be a false positive. I obviously had no symptoms when I got the dysport nor did I have them… read more

June 6, 2025
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It's important to understand that seronegative MG is a known variant, affecting about 10% of people with MG. The diagnostic process can be complex and sometimes take months or years to confirm. While waiting for your neurologist appointment, know that having seronegative results doesn't rule out MG, especially given your Show Full Answer

It's important to understand that seronegative MG is a known variant, affecting about 10% of people with MG. The diagnostic process can be complex and sometimes take months or years to confirm. While waiting for your neurologist appointment, know that having seronegative results doesn't rule out MG, especially given your positive ice pack test and symptoms. Newer, more precise testing methods like cell-based assays are becoming available and have shown that some initially seronegative patients may actually have detectable antibodies. In fact, studies show that almost 20% of people initially diagnosed as seronegative were later found to have AChR antibodies when tested with newer methods. Common MG symptoms include ptosis (droopy eyelid), blurry or double vision, and changes in facial expressions - which align with your ocular symptoms. While waiting for your August appointment, consider asking to be put on a cancellation list if you haven't already, and keep detailed notes of your symptoms and their timing to share with your neurologist.

June 6, 2025

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