Hyoscyamine for Myasthenia Gravis | MGteam

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Hyoscyamine is a prescription medication used to control symptoms associated with various health conditions related to the stomach and gastrointestinal (GI) tract, including bladder spasms, irritable bowel syndrome, pancreatitis, and peptic ulcer disease. A doctor also may prescribe it to control GI-related side effects of acetylcholinesterase inhibitors, like pyridostigmine, which are used to treat myasthenia gravis.

Hyoscyamine is a member of a class of drugs called anticholinergic agents and is also considered an antispasmodic. It’s believed to work by relaxing muscles in the digestive tract and bladder and by reducing how much sweat, saliva, and stomach acid a person produces.

How is it taken?
Hyoscyamine comes in the form of a tablet, extended release capsule, or a liquid. All are taken orally. For treating side effects from acetylcholinesterase inhibitors in people with myasthenia gravis, a doctor may prescribe it three times daily or with each dose of the acetylcholinesterase inhibitor. Your doctor will instruct you on how to take it.

Side effects
Common side effects of hyoscyamine may include blurry vision, dizziness, drowsiness, weakness, decreased sweating, decreased urination, rash, dry mouth, decease in sense of taste, stomach upset, vomiting, bloating, diarrhea, constipation, headache, insomnia, photosensitivity (sensitivity to light), and sexual difficulties.

Serious side effects may include allergic reactions such as rash, itching, hives, and swelling of the face, lips, and throat; blockage of the bowel; diarrhea; ongoing fever; rapid, irregular heartbeat; anxiety, confusion, and hallucinations; and difficulty urinating.

For more details about this treatment, visit:

Overview of the Treatment of Myasthenia Gravis — Wolters Kluwer UpToDate

Hyoscyamine Tablets — Cleveland Clinic

Hyoscyamine — MedlinePlus

Hyoscyamine — Drugs.com

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